PDGFRA Antibody

Product Specifications

Background

PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.

NCBI Gene ID

5156

Swiss Prot

P16234

Accession Number

P16234

Host

Rabbit

Reactivity

Human

Immunogen

This PDGFRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 746-775 amino acids from human PDGFRA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

123 kDa

Fragment

Rabbit Ig

Symbol

PDGFRA

NCBI Official Name

Platelet-derived growth factor receptor alpha

NCBI Organism

Homo sapiens

Background Reference 01

Wilczynski, S.P., et al., Hum. Pathol. 36 (3) :242-249 (2005) .

Background Reference 02

Hiwatari, M., et al., Leukemia 19 (3) :476-477 (2005) .

Background Reference 03

Debiec-Rychter, M., et al., Gastroenterology 128 (2) :270-279 (2005) .

Background Reference 04

Sakurai, S., et al., Hum. Pathol. 35 (10) :1223-1230 (2004) .

Other Product Names

Platelet-derived growth factor receptor alpha, PDGF-R-alpha, PDGFR-alpha, Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a antigen, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor 2, PDGFR-2, CD140a, PDGFRA, PDGFR2, RHEPDGFRA