MUSK Antibody

Product Specifications

Background

MuSK activates signaling cascades responsible for many aspects of synapse formation, including the organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation. MuSK also mediates agrin-induced aggregation of acetylcholine receptors at the mature vertebrate neuromuscular junction and also during synapse formation. It has been shown that a majority of AChR Ab-seronegative myasthenia gravis patients possess serum autoantibodies against MuSK.

NCBI Gene ID

4593

Swiss Prot

O15146

Accession Number

O15146

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MUSK antibody is generated from rabbits immunized with human MUSK recombinant protein.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

97 kDa

Fragment

Rabbit Ig

Symbol

MUSK

NCBI Official Name

Muscle, skeletal receptor tyrosine-protein kinase

NCBI Organism

Homo sapiens

Background Reference 01

Blume-Jensen P, et al. Nature 2001. 411: 355.

Background Reference 02

Cantrell D, J. Cell Sci. 2001. 114: 1439.

Background Reference 03

JhiangOncogene 2000. 19: 5590.

Background Reference 04

Manning G, et al. Science 2002. 298: 1912.

Other Product Names

Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor, MUSK

Tested Applications

WB, IF, Flow

Physical Properties

Liquid

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