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CPE Antibody

Product Specifications

Background

CPE is a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in CPE gene are implicated in type II diabetes.

NCBI Gene ID

1363

Swiss Prot

P16870

Accession Number

P16870

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This CPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-412 amino acids from the C-terminal region of human CPE.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

53 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CPE

NCBI Official Name

Carboxypeptidase E

NCBI Organism

Homo sapiens

Background Reference 01

Oiso, S., J. Neurochem. 109 (1), 158-167 (2009)

Background Reference 02

Yang, L., Ann. N. Y. Acad. Sci. 1150, 263-266 (2008)

Background Reference 03

Jeffrey, K.D., Proc. Natl. Acad. Sci. U.S.A. 105 (24), 8452-8457 (2008)

Other Product Names

Carboxypeptidase E, CPE, Carboxypeptidase H, CPH, Enkephalin convertase, Prohormone-processing carboxypeptidase, CPE

Tested Applications

WB

Protein ID

115892

Physical Properties

Liquid

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