KIT Antibody

Product Specifications

Background

KIT is the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor) . Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.

NCBI Gene ID

3815

Swiss Prot

P10721

Accession Number

P10721

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This KIT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human KIT.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

110 kDa

Fragment

Rabbit Ig

Symbol

KIT

NCBI Official Name

Mast/stem cell growth factor receptor Kit

NCBI Organism

Homo sapiens

Background Reference 01

Wardelmann, E., et al., Int. J. Cancer 106 (6) :887-895 (2003) . Lennartsson, J., et al., Exp. Cell Res. 288 (1) :110-118 (2003) . Sakuma, Y., et al., Cancer Sci 94 (6) :486-491 (2003) . Araki, K., et al., Lung Cancer 40 (2) :173-180 (2003) . Voytyuk, O., et al., J. Biol. Chem. 278 (11) :9159-9166 (2003) .

Other Product Names

Mast/stem cell growth factor receptor Kit, SCFR, Piebald trait protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, CD117, KIT, SCFR