IGF1R Antibody

Product Specifications

Background

The IGF1R receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.

NCBI Gene ID

3480

Swiss Prot

P08069

Accession Number

P08069

Host

Rabbit

Reactivity

Human

Immunogen

This IGF1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-77 amino acids from the N-terminal region of human IGF1R.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

155 kDa

Fragment

Rabbit Ig

Symbol

IGF1R

NCBI Official Name

Insulin-like growth factor 1 receptor

NCBI Organism

Homo sapiens

Background Reference 01

Song, R.X., et al., Proc. Natl. Acad. Sci. U.S.A. 101 (7) :2076-2081 (2004) .

Background Reference 02

Zhao, H., et al., Oncogene 23 (3) :786-794 (2004) .

Background Reference 03

Lu, Y., et al., Biochem. Biophys. Res. Commun. 313 (3) :709-715 (2004) .

Background Reference 04

Hakam, A., et al., Dig. Dis. Sci. 48 (10) :1972-1978 (2003) .

Other Product Names

Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, IGF-I receptor, CD221, Insulin-like growth factor 1 receptor alpha chain, Insulin-like growth factor 1 receptor beta chain, IGF1R