KDR Antibody

Product Specifications

Background

KDR is a major growth factor for endothelial cells. This protein encodes one of the two receptors of the KDR. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc..

NCBI Gene ID

3791

Swiss Prot

P35968

Accession Number

P35968

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This KDR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1153-1182 amino acids from human KDR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

152 kDa

Fragment

Rabbit Ig

Symbol

KDR

NCBI Official Name

Vascular endothelial growth factor receptor 2

NCBI Organism

Homo sapiens

Background Reference 01

Huang, D., et al. Cancer Res. 70 (3) :1053-1062 (2010)

Background Reference 02

Sentilhes, L., et al. J. Neuropathol. Exp. Neurol. 69 (2) :111-128 (2010)

Background Reference 03

Lamalice, L., et al. J. Biol. Chem. 281 (45) :34009-34020 (2006)

Background Reference 04

Meyer, R.D., et al. J. Biol. Chem. 277 (30) :27081-27087 (2002)

Other Product Names

Vascular endothelial growth factor receptor 2, VEGFR-2, Fetal liver kinase 1, FLK-1, Kinase insert domain receptor, KDR, Protein-tyrosine kinase receptor flk-1, CD309, KDR, FLK1, VEGFR2