FGFR1 Antibody

Product Specifications

Background

FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome.

NCBI Gene ID

2260

Swiss Prot

P11362

Accession Number

P11362

Host

Rabbit

Reactivity

Human

Immunogen

This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-161 amino acids from human FGFR1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

92 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

FGFR1

NCBI Official Name

Fibroblast growth factor receptor 1

NCBI Organism

Homo sapiens

Background Reference 01

Jiao, J., et al., Arch. Biochem. Biophys. 410 (2) :187-200 (2003) .

Background Reference 02

Fu, L., et al., J. Comp. Neurol. 462 (2) :265-273 (2003) .

Background Reference 03

Lundin, L., et al., Exp. Cell Res. 287 (1) :190-198 (2003) .

Background Reference 04

Kiselyov, V.V., et al., Structure (Camb.) 11 (6) :691-701 (2003) .

Other Product Names

Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR