NAB2 Antibody

Product Specifications

Background

NAB2 is a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by this protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex.

NCBI Gene ID

4665

Swiss Prot

Q15742

Accession Number

Q15742

Host

Rabbit

Reactivity

Human

Immunogen

This NAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human NAB2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NAB2

NCBI Official Name

NGFI-A-binding protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Srinivasan, R., J. Biol. Chem. 281 (22), 15129-15137 (2006)

Background Reference 02

Kumbrink, J., J. Biol. Chem. 280 (52), 42785-42793 (2005)

Background Reference 03

Lucerna, M., J. Biol. Chem. 278 (13), 11433-11440 (2003)

Other Product Names

NGFI-A-binding protein 2, EGR-1-binding protein 2, Melanoma-associated delayed early response protein, Protein MADER, NAB2, MADER

Tested Applications

Protein ID

12643729

Physical Properties

Liquid

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