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EGFR Antibody

Product Specifications

Background

The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4) . Mutations affecting EGFR expression or activity could result in cancer.

NCBI Gene ID

1956

Swiss Prot

P00533

Accession Number

P00533

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1048-1077 amino acids from human EGFR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

134 kDa

Fragment

Rabbit Ig

Symbol

EGFR

NCBI Official Name

Epidermal growth factor receptor

NCBI Organism

Homo sapiens

Background Reference 01

Zanardi, T.A., et al., J. Virol. 77 (21) :11685-11696 (2003) .

Background Reference 02

Krug, A.W., et al., J. Biol. Chem. 278 (44) :43060-43066 (2003) .

Background Reference 03

Huang, F., et al., J. Biol. Chem. 278 (44) :43411-43417 (2003) .

Background Reference 04

He, Y.Y., et al., J. Biol. Chem. 278 (43) :42457-42465 (2003) .

Other Product Names

Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1

Tested Applications

WB, IHC-P

Protein ID

2811086

Physical Properties

Liquid

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