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EphB6 Antibody

Product Specifications

Background

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.

NCBI Gene ID

2051

Swiss Prot

O15197

Accession Number

O15197

Host

Rabbit

Reactivity

Human

Immunogen

This EphB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human EphB6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=63-064

Calculated Molecular Weight

111 kDa

Fragment

Rabbit Ig

Symbol

EPHB6

NCBI Official Name

Ephrin type-B receptor 6

NCBI Organism

Homo sapiens

Background Reference 01

Freywald, A., et al., J. Biol. Chem. 278 (12) :10150-10156 (2003) .

Background Reference 02

Luo, H., et al., J. Clin. Invest. 110 (8) :1141-1150 (2002) .

Background Reference 03

Wilkinson, D.G., Nat Rev Neurosci 2 (3) :155-164 (2001) .

Background Reference 04

Luo, H., et al., J. Immunol. 167 (3) :1362-1370 (2001) .

Other Product Names

Ephrin type-B receptor 6, HEP, Tyrosine-protein kinase-defective receptor EPH-6, EPHB6

Tested Applications

WB, IHC-P, Flow

Physical Properties

Liquid

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