PCSK2 Antibody

Product Specifications

Background

PCSK2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.

NCBI Gene ID

5126

Swiss Prot

P16519

Accession Number

P16519

Host

Rabbit

Reactivity

Human

Immunogen

This PCSK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-346 amino acids from the Central region of human PCSK2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

71 kDa

Fragment

Rabbit Ig

Symbol

PCSK2

NCBI Official Name

Neuroendocrine convertase 2

NCBI Organism

Homo sapiens

Background Reference 01

Leak, T.S., Keene, K.L. Mol. Genet. Metab. 92 (1-2), 145-150 (2007)

Background Reference 02

Shen, X., Li, Q.L. Am. J. Physiol. Endocrinol. Metab. 288 (1), E236-E245 (2005)

Background Reference 03

Tzimas, G.N., Chevet, E. BMC Cancer 5, 149 (2005)

Background Reference 04

Seidah, N.G., Mattei, M.G. Genomics 11 (1), 103-107 (1991)

Other Product Names

Neuroendocrine convertase 2, NEC 2, KEX2-like endoprotease 2, Prohormone convertase 2, Proprotein convertase 2, PC2, PCSK2, NEC2

Tested Applications

WB, IHC-P, Flow

Protein ID

13124785

Physical Properties

Liquid

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