ALK Antibody
Product Specifications
Background
ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t (2;5) (p23; q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.
NCBI Gene ID
238
Swiss Prot
Q9UM73
Accession Number
Q9UM73
Host
Rabbit
Reactivity
Human
Immunogen
This ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1591~1620 amino acids from the C-terminal region of human ALK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
176 kDa
Fragment
Rabbit Ig
Applications Notes
For IHC-P starting dilution is: 1:50~100
Symbol
ALK
NCBI Official Name
ALK tyrosine kinase receptor
NCBI Organism
Homo sapiens
Background Reference 01
Morris, S.W., et al., Oncogene 14 (18) :2175-2188 (1997) .
Background Reference 02
Iwahara, T., et al., Oncogene 14 (4) :439-449 (1997) .
Background Reference 03
Morris, S.W., et al., Science 263 (5151) :1281-1284 (1994) .
Background Reference 04
Morris, S.W., et al., Oncogene 15, 2883-2883 (1997) .
Other Product Names
ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Tested Applications
IHC-P
Protein ID
296439447
Physical Properties
Liquid
Curated Selection
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