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PTPN7 Antibody

Product Specifications

Background

PTPN7 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN7 is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP has been shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to function through dephosphorylating the molecules related to MAP kinase pathway.

NCBI Gene ID

5778

Swiss Prot

P35236

Accession Number

P35236

Host

Rabbit

Reactivity

Human

Immunogen

This PTPN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from human PTPN7.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Symbol

PTPN7

NCBI Official Name

Tyrosine-protein phosphatase non-receptor type 7

NCBI Organism

Homo sapiens

Background Reference 01

Eswaran, J., Biochem. J. 395 (3), 483-491 (2006)

Background Reference 02

Mustelin, T., J. Mol. Biol. 354 (1), 150-163 (2005)

Background Reference 03

Pettiford, S.M., Leukemia 17 (2), 366-378 (2003)

Background Reference 04

Kosaki, K., J. Clin. Endocrinol. Metab. 87 (8), 3529-3533 (2002)

Other Product Names

Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, HEPTP, Protein-tyrosine phosphatase LC-PTP, PTPN7

Tested Applications

WB, IHC-P

Protein ID

20141721

Physical Properties

Liquid

Frequently Asked Questions

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