CUL5 Antibody
Product Specifications
Background
CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS (SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.
NCBI Gene ID
8065
Swiss Prot
Q93034
Accession Number
Q93034
Host
Rabbit
Reactivity
Human
Immunogen
This CUL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 747-774 amino acids from the C-terminal region of human CUL5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rb
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
91 kDa
Fragment
Rabbit Ig
Symbol
CUL5
NCBI Official Name
Cullin-5
NCBI Organism
Homo sapiens
Background Reference 01
Kamura T., Burian D., Yan Q.J. Biol. Chem. 276:29748-29753 (2001)
Background Reference 02
Mehle A., Goncalves J., Santa-Marta M.Genes Dev. 18:2861-2866 (2004)
Background Reference 03
Kamura T., Maenaka K., Kotoshiba S.Genes Dev. 18:3055-3065 (2004)
Other Product Names
Cullin-5, CUL-5, Vasopressin-activated calcium-mobilizing receptor 1, VACM-1, CUL5, VACM1
Tested Applications
WB, IHC-P, Flow
Protein ID
14917099
Physical Properties
Liquid
Curated Selection
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