PUM1 Antibody

Product Specifications

Background

PUM1 is a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. This protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of this protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation.

NCBI Gene ID

9698

Swiss Prot

Q14671

Accession Number

Q14671

Host

Rabbit

Reactivity

Human

Immunogen

This PUM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from human PUM1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Chicken

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

126 kDa

Fragment

Rabbit Ig

Symbol

PUM1

NCBI Official Name

Pumilio homolog 1

NCBI Organism

Homo sapiens

Background Reference 01

Gupta, Y.K., Structure 16 (4), 549-557 (2008)

Background Reference 02

Spassov, D.S., IUBMB Life 55 (7), 359-366 (2003)

Background Reference 03

Spassov, D.S., Gene 299 (1-2), 195-204 (2002)

Other Product Names

Pumilio homolog 1, HsPUM, Pumilio-1, PUM1, KIAA0099, PUMH1

Tested Applications

WB, IHC-P

Protein ID

41688619

Physical Properties

Liquid

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