ACAT1 Antibody

Product Specifications

Background

ACAT1 is a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in the gene encoding ACAT1 are associated with the alpha-methylacetoaceticaciduria disorder, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.

NCBI Gene ID

Swiss Prot

P24752

Accession Number

P24752

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This ACAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-329 amino acids from the C-terminal region of human ACAT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Symbol

ACAT1

NCBI Official Name

Acetyl-CoA acetyltransferase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Locke, J.A., Prostate 68 (1), 20-33 (2008)

Background Reference 02

Guo, Z.Y., Biochemistry 46 (35), 10063-10071 (2007)

Background Reference 03

Haapalainen, A.M., Biochemistry 46 (14), 4305-4321 (2007)

Other Product Names

Acetyl-CoA acetyltransferase, mitochondrial, Acetoacetyl-CoA thiolase, T2, ACAT1, ACAT, MAT

Tested Applications

WB, IHC-P

Protein ID

135755

Physical Properties

Liquid

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