Thrombopoietin Antibody

Product Specifications

Background

Megakaryocytopoiesis is the cellular development process that leads to platelet production. THPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. It is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.

NCBI Gene ID

7066

Swiss Prot

P40225

Accession Number

P40225

Host

Rabbit

Reactivity

Human

Immunogen

This Thrombopoietin (TPO) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-273 amino acids from the Central region of human Thrombopoietin (TPO) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Cell Cycle, Immunology, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

38 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

THPO

NCBI Official Name

Thrombopoietin

NCBI Organism

Homo sapiens

Background Reference 01

Baker, J.E., Cardiovasc. Res. 77 (1), 44-53 (2008)

Background Reference 02

Steinberg, O., J. Pediatr. Hematol. Oncol. 29 (12), 822-825 (2007)

Background Reference 03

Kanayasu-Toyoda, T., J. Biol. Chem. 282 (46), 33507-33514 (2007)

Other Product Names

Thrombopoietin, C-mpl ligand, ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand, THPO, MGDF