MAK Antibody

MAK is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.

This MAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 578-608 amino acids from the C-terminal region of human MAK.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Xia, L., et al., J. Biol. Chem. 277 (38) :35422-35433 (2002) . Taketo, M., et al., Genomics 19 (2) :397-398 (1994) . Jinno, A., et al., Mol. Cell. Biol. 13 (7) :4146-4156 (1993) . Bladt, F., et al., Differentiation 53 (2) :115-122 (1993) . Koji, T., et al., Cell Biochem. Funct. 10 (4) :273-279 (1992) .