CLK1 Antibody

Product Specifications

Background

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.

NCBI Gene ID

1195

Swiss Prot

P49759

Accession Number

P49759

Host

Rabbit

Reactivity

Human

Immunogen

This CLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-99 amino acids from the N-terminal region of human CLK1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CLK1

NCBI Official Name

Dual specificity protein kinase CLK1

NCBI Organism

Homo sapiens

Background Reference 01

Prasad, J., et al., Mol. Cell. Biol. 23 (12) :4139-4149 (2003) . Talmadge, C.B., et al., Hum. Genet. 103 (4) :523-524 (1998) . Hanes, J., et al., J. Mol. Biol. 244 (5) :665-672 (1994) . Johnson, K.W., et al., J. Biol. Chem. 266 (6) :3402-3407 (1991) . Ben-David, Y., et al., EMBO J. 10 (2) :317-325 (1991) .