PKM1 Antibody
Product Specifications
Background
PKM1 is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. The protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis.
NCBI Gene ID
5315
Swiss Prot
P14618
Accession Number
P14618
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PKM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-417 amino acids from the C-terminal region of human PKM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=62-940
Calculated Molecular Weight
58 kDa
Fragment
Rabbit Ig
Symbol
PKM
NCBI Official Name
Pyruvate kinase PKM
NCBI Organism
Homo sapiens
Background Reference 01
Dombrauckas J.D.Biochemistry 44:9417-9429 (2005) Daub H., Olsen J.V.Mol. Cell 31:438-448 (2008) Ashizawa K., McPhie P.Biochemistry 30:7105-7111 (1991)
Other Product Names
Pyruvate kinase PKM, Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58, PKM, OIP3, PK2, PK3, PKM2
Tested Applications
WB, IHC-P
Protein ID
20178296
Physical Properties
Liquid
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