ADAMTS13 Antibody

Product Specifications

Background

ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF) -cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.

NCBI Gene ID

11093

Swiss Prot

Q76LX8

Accession Number

Q76LX8

Host

Rabbit

Reactivity

Human

Immunogen

This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 amino acids from the Central region of human ADAMTS13.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

154 kDa

Fragment

Rabbit Ig

Symbol

ADAMTS13

NCBI Official Name

A disintegrin and metalloproteinase with thrombospondin motifs 13

NCBI Organism

Homo sapiens

Background Reference 01

Zheng X., Chung D., Takayama T.K.J. Biol. Chem. 276:41059-41063 (2001)

Background Reference 02

Levy G.G., Nichols W.C.Nature 413:488-494 (2001)

Background Reference 03

Cal S., Obaya A.J., Llamazares M., Garabaya C.Gene 283:49-62 (2002)

Background Reference 04

Zheng X., Nishio K., Majerus E.M.J. Biol. Chem. 278:30136-30141 (2003)

Other Product Names

A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8