ABCC4 Antibody

Product Specifications

Background

ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.

NCBI Gene ID

10257

Swiss Prot

O15439

Accession Number

O15439

Host

Rabbit

Reactivity

Human

Immunogen

This ABCC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1117-1145 amino acids from the C-terminal region of human ABCC4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

150 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ABCC4

NCBI Official Name

Multidrug resistance-associated protein 4

NCBI Organism

Homo sapiens

Background Reference 01

Lee K., Belinsky M.G., Bell D.W.Cancer Res. 58:2741-2747 (1998)

Background Reference 02

Adachi M., Sampath J., Lan L.B.J. Biol. Chem. 277:38998-39004 (2002)

Background Reference 03

Kool M., de Haas M., Scheffer G.L.Cancer Res. 57:3537-3547 (1997)

Background Reference 04

Janke D., Mehralivand S., Strand D.Hum. Mutat. 29:659-669 (2008)

Other Product Names

Multidrug resistance-associated protein 4, ATP-binding cassette sub-family C member 4, MRP/cMOAT-related ABC transporter, Multi-specific organic anion transporter B, MOAT-B, ABCC4, MRP4