Mouse DHFR Antibody
Product Specifications
Background
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
NCBI Gene ID
13361
Swiss Prot
P00375
Accession Number
P00375
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
This Mouse DHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the C-terminal region of mouse DHFR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Symbol
Dhfr
NCBI Official Name
Dihydrofolate reductase
NCBI Organism
Mus musculus
Background Reference 01
Cody, V., Proteins 65 (4), 959-969 (2006)
Background Reference 02
Stone, D., J. Biol. Chem. 254 (2), 480-488 (1979)
Other Product Names
Dihydrofolate reductase, Dhfr
Tested Applications
WB, IHC-P
Physical Properties
Liquid
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