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PCSK9 Antibody

Product Specifications

Background

PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

NCBI Gene ID

255738

Swiss Prot

Q8NBP7

Accession Number

Q8NBP7

Host

Rabbit

Reactivity

Human

Immunogen

This PCSK9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the N-terminal region of human PCSK9.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-831

Calculated Molecular Weight

74 kDa

Fragment

Rabbit Ig

Symbol

PCSK9

NCBI Official Name

Proprotein convertase subtilisin/kexin type 9

NCBI Organism

Homo sapiens

Background Reference 01

Abifadel, M., Rabes, J.P. Hum. Mutat. 30 (7), E682-E691 (2009)

Background Reference 02

McNutt, M.C., Kwon, H.J. J. Biol. Chem. 284 (16), 10561-10570 (2009)

Background Reference 03

Shioji, K., Mannami, T. J. Hum. Genet. 49 (2), 109-114 (2004)

Background Reference 04

Abifadel, M., Varret, M. Nat. Genet. 34 (2), 154-156 (2003)

Other Product Names

Proprotein convertase subtilisin/kexin type 9, 3421-, Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9, PCSK9, NARC1

Tested Applications

WB, IHC-P, Flow

Protein ID

317373487

Physical Properties

Liquid

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