PCSK9 Antibody
Product Specifications
Background
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
NCBI Gene ID
255738
Swiss Prot
Q8NBP7
Accession Number
Q8NBP7
Host
Rabbit
Reactivity
Human
Immunogen
This PCSK9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the N-terminal region of human PCSK9.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
74 kDa
Fragment
Rabbit Ig
Symbol
PCSK9
NCBI Official Name
Proprotein convertase subtilisin/kexin type 9
NCBI Organism
Homo sapiens
Background Reference 01
Abifadel, M., Rabes, J.P. Hum. Mutat. 30 (7), E682-E691 (2009)
Background Reference 02
McNutt, M.C., Kwon, H.J. J. Biol. Chem. 284 (16), 10561-10570 (2009)
Background Reference 03
Shioji, K., Mannami, T. J. Hum. Genet. 49 (2), 109-114 (2004)
Background Reference 04
Abifadel, M., Varret, M. Nat. Genet. 34 (2), 154-156 (2003)
Other Product Names
Proprotein convertase subtilisin/kexin type 9, 3421-, Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9, PCSK9, NARC1
Tested Applications
WB, IHC-P, Flow
Protein ID
317373487
Physical Properties
Liquid
Frequently Asked Questions
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