Neprilysin Antibody

Product Specifications

Background

MME is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) . This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a oprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.

NCBI Gene ID

4311

Swiss Prot

P08473

Accession Number

P08473

Host

Rabbit

Reactivity

Human

Immunogen

This Neprilysin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from the C-terminal region of human Neprilysin.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Rabbit

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

86 kDa

Fragment

Rabbit Ig

Symbol

MME

NCBI Official Name

Neprilysin

NCBI Organism

Homo sapiens

Background Reference 01

Dakka, N., Bellaoui, H. Pediatr Hematol Oncol 26 (4), 216-231 (2009)

Background Reference 02

Wang, R., Wang, S. J. Neurochem. 108 (4), 1072-1082 (2009)

Background Reference 03

Shipp, M.A. Proc. Natl. Acad. Sci. U.S.A. 88 (23), 10662-10666 (1991)

Background Reference 04

Shipp, M.A. Proc. Natl. Acad. Sci. U.S.A. 86 (1), 297-301 (1989)

Other Product Names

Neprilysin, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, Enkephalinase, Neutral endopeptidase 2411, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, CD10, MME, EPN