HRG Antibody
Product Specifications
Background
HRG contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.
NCBI Gene ID
3273
Swiss Prot
P04196
Accession Number
P04196
Host
Rabbit
Reactivity
Human
Immunogen
This HRG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human HRG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Symbol
HRG
NCBI Official Name
Histidine-rich glycoprotein
NCBI Organism
Homo sapiens
Background Reference 01
Vanwildemeersch, M., Olsson, A.K. J. Biol. Chem. 281 (15), 10298-10304 (2006)
Background Reference 02
Jones, A.L., Poon, I.K. J. Biol. Chem. 280 (42), 35733-35741 (2005)
Background Reference 03
Hennis, B.C. and Kluft, C. Nucleic Acids Res. 19 (15), 4311 (1991)
Other Product Names
Histidine-rich glycoprotein, Histidine-proline-rich glycoprotein, HPRG, HRG
Tested Applications
WB, IHC-P
Protein ID
123523
Physical Properties
Liquid
Curated Selection
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