Aromatase Antibody

Product Specifications

Background

CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.

NCBI Gene ID

1588

Swiss Prot

P11511

Accession Number

P11511

Host

Rabbit

Reactivity

Human

Immunogen

This Aromatase (CYP19A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-253 amino acids from the Central region of human Aromatase (CYP19A1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Neuroscience

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rb

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

58 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CYP19A1

NCBI Official Name

Aromatase

NCBI Organism

Homo sapiens

Background Reference 01

Ikeda, S., Am. J. Gastroenterol. 103 (6), 1476-1487 (2008)

Background Reference 02

Dos Santos, (er) DNA Cell Biol. (2008) In press

Background Reference 03

Nelson, Pharmacogenetics 14 (1), 1-18 (2004)

Other Product Names

Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19

Tested Applications

Protein ID

117293

Physical Properties

Liquid

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