NAE1 Antibody

Product Specifications

Background

APPBP1 binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties thought to play a role in the pathogenesis of Alzheimer's disease. In addition, this protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. APPB1 is required for cell cycle progression through the S/M checkpoint.

NCBI Gene ID

8883

Swiss Prot

Q13564

Accession Number

Q13564

Host

Rabbit

Reactivity

Human

Immunogen

This NAE1 (APPBP1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 430-459 amino acids from the C-terminal region of human NAE1 (APPBP1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Symbol

NAE1

NCBI Official Name

NEDD8-activating enzyme E1 regulatory subunit

NCBI Organism

Homo sapiens

Background Reference 01

Chen, Y., J. Cell Biol. 163 (1), 27-33 (2003)

Background Reference 02

Chen, Y., J. Neurochem. 85 (3), 801-809 (2003)

Background Reference 03

Walden, H., Nature 422 (6929), 330-334 (2003)

Background Reference 04

Chow, N., J. Biol. Chem. 271 (19), 11339-11346 (1996)

Other Product Names

NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1, NAE1, APPBP1