AMPK alpha Antibody

Product Specifications

Background

PRKAA1 belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK) . AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.

NCBI Gene ID

5562

Swiss Prot

Q13131

Accession Number

Q13131

Host

Rabbit

Reactivity

Human

Immunogen

This AMPK alpha (PRKAA1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-502 amino acids from human AMPK alpha (PRKAA1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Neuroscience, Signal Transduction, Autophagy

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

64 kDa

Fragment

Rabbit Ig

Symbol

PRKAA1

NCBI Official Name

5'-AMP-activated protein kinase catalytic subunit alpha-1

NCBI Organism

Homo sapiens

Background Reference 01

Pang, T., J. Biol. Chem. 282 (1), 495-506 (2007)

Background Reference 02

Crawford, R.M., Cell. Signal. 18 (10), 1595-1603 (2006)

Background Reference 03

Crawford, R.M., Mol. Cell. Biol. 26 (15), 5921-5931 (2006)

Other Product Names

5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1, PRKAA1, AMPK1