Cdc25B Antibody
Product Specifications
Background
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined.
NCBI Gene ID
994
Swiss Prot
P30305
Accession Number
P30305
Host
Rabbit
Reactivity
Human
Immunogen
This Cdc25B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the N-terminal region of human Cdc25B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CDC25B
NCBI Official Name
M-phase inducer phosphatase 2
NCBI Organism
Homo sapiens
Background Reference 01
Uchida, S., et al., Biochem. Biophys. Res. Commun. 316 (1) :226-232 (2004) .
Background Reference 02
Ito, Y., et al., Int. J. Mol. Med. 13 (3) :431-435 (2004) .
Background Reference 03
Wu, W., et al., Cancer Res. 63 (19) :6195-6199 (2003) .
Background Reference 04
Mils, V., et al., Exp. Cell Res. 285 (1) :99-106 (2003) .
Other Product Names
M-phase inducer phosphatase 2, Dual specificity phosphatase Cdc25B, CDC25B, CDC25HU2
Tested Applications
WB
Protein ID
21264471
Physical Properties
Liquid
Frequently Asked Questions
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