Aurora-B Antibody

Product Specifications

Background

Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. STK12 (Aurora kinase B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A localizes to centrosomes

NCBI Gene ID

9212

Swiss Prot

Q96GD4

Accession Number

Q96GD4

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This Aurora-B (ARK/STK12) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-313 amino acids from the Central region of human Aurora-B (ARK/STK12) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Symbol

AURKB

NCBI Official Name

Aurora kinase B

NCBI Organism

Homo sapiens

Background Reference 01

Kimura, M., et al., Biochem. Biophys. Res. Commun. 316 (3) :930-936 (2004) .

Background Reference 02

Yasui, Y., et al., J. Biol. Chem. 279 (13) :12997-13003 (2004) .

Background Reference 03

Lampson, M.A., et al., Nat. Cell Biol. 6 (3) :232-237 (2004) .

Background Reference 04

Wheatley, S.P., et al., J. Biol. Chem. 279 (7) :5655-5660 (2004) .

Other Product Names

Aurora kinase B, Aurora 1, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, ARK-2, Aurora-related kinase 2, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B, AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5