SPHK1 Antibody
Product Specifications
Background
SPHK1 is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974) . Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.
NCBI Gene ID
8877
Swiss Prot
Q9NYA1
Accession Number
Q9NYA1
Host
Rabbit
Reactivity
Human
Immunogen
This SPHK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-343 amino acids from the C-terminal region of human SPHK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Symbol
SPHK1
NCBI Official Name
Sphingosine kinase 1
NCBI Organism
Homo sapiens
Background Reference 01
Hengst, J.A., et al. Arch. Biochem. Biophys. 494 (1) :23-31 (2010)
Background Reference 02
Jarman, K.E., et al. J. Biol. Chem. 285 (1) :483-492 (2010)
Background Reference 03
Gamble, J.R., et al. Am. J. Pathol. 175 (5) :2217-2225 (2009)
Other Product Names
Sphingosine kinase 1, SK 1, SPK 1, SPHK1, SPHK, SPK
Tested Applications
WB, IHC-P, Flow
Protein ID
17369329
Physical Properties
Liquid
Curated Selection
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