What is the catalog number for MAPK14 Antibody?

The catalog number for MAPK14 Antibody is 62-741.

What sizes are available for MAPK14 Antibody?

MAPK14 Antibody is available in the following size(s): 400 µL.

Is MAPK14 Antibody in stock?

MAPK14 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

MAPK14 Antibody

Product Specifications

Background

MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

NCBI Gene ID

1432

Swiss Prot

Q16539

Accession Number

Q16539

Host

Rabbit

Reactivity

Human

Immunogen

This MAPK14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-187 amino acids from human MAPK14.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Zebrafish, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

41 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MAPK14

NCBI Official Name

Mitogen-activated protein kinase 14

NCBI Organism

Homo sapiens

Background Reference 01

Cheung, P.C., et al., EMBO J. 22 (21) :5793-5805 (2003) .

Background Reference 02

Dean, J.L., et al., J. Biol. Chem. 278 (41) :39470-39476 (2003) .

Background Reference 03

Sun, A., et al., Exp. Neurol. 183 (2) :394-405 (2003) .

Background Reference 04

Yustein, J.T., et al., Oncogene 22 (40) :6129-6141 (2003) .

Other Product Names

Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a, SAPK2a, MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A