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AMPK alpha2 Antibody

Product Specifications

Background

AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

NCBI Gene ID

5563

Swiss Prot

P54646

Accession Number

P54646

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This AMPK alpha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-507 amino acids from the C-terminal region of human AMPK alpha2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-728

Calculated Molecular Weight

62 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PRKAA2

NCBI Official Name

5'-AMP-activated protein kinase catalytic subunit alpha-2

NCBI Organism

Homo sapiens

Background Reference 01

Minokoshi, Y., et al., Nature 428 (6982) :569-574 (2004) .

Background Reference 02

Andersson, U., et al., J. Biol. Chem. 279 (13) :12005-12008 (2004) .

Background Reference 03

Browne, G.J., et al., J. Biol. Chem. 279 (13) :12220-12231 (2004) .

Background Reference 04

Shaw, R.J., et al., Proc. Natl. Acad. Sci. U.S.A. 101 (10) :3329-3335 (2004) .

Other Product Names

5'-AMP-activated protein kinase catalytic subunit alpha-2, AMPK subunit alpha-2, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, PRKAA2, AMPK, AMPK2

Tested Applications

WB

Protein ID

20178276

Physical Properties

Liquid

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