MYT1 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Transcript Variant: This variant (1) encodes the longer isoform (1) .

NCBI Gene ID

9088

Swiss Prot

Q99640

Accession Number

Q99640

Host

Rabbit

Reactivity

Human

Immunogen

This MYT1 (PKMYT1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-482 amino acids from the C-terminal region of human MYT1 (PKMYT1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

55 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PKMYT1

NCBI Official Name

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

NCBI Organism

Homo sapiens

Background Reference 01

Dai, X., et al., J. Invest. Dermatol. 122 (6) :1356-1364 (2004) .

Background Reference 02

Nakajima, H., et al., J. Biol. Chem. 278 (28) :25277-25280 (2003) .

Background Reference 03

Passer, B.J., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (5) :2284-2289 (2003) .

Background Reference 04

Okumura, E., et al., Nat. Cell Biol. 4 (2) :111-116 (2002) .

Other Product Names

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, Myt1 kinase, PKMYT1, MYT1

Tested Applications

Protein ID

55976573

Physical Properties

Liquid

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