HMGB2 Antibody

Product Specifications

Background

HMGB2 is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V (D) J recombination.

NCBI Gene ID

3148

Swiss Prot

P26583

Accession Number

P26583

Host

Rabbit

Reactivity

Human

Immunogen

This HMGB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-118 amino acids from the Central region of human HMGB2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

24 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

HMGB2

NCBI Official Name

High mobility group protein B2

NCBI Organism

Homo sapiens

Background Reference 01

Majumdar A., Brown D. 19:6643-6643 (1991)

Background Reference 02

Shirakawa H., Yoshida M.J.. 267:6641-6645 (1992)

Background Reference 03

Alexandre S., Li W.W.Nucleic Acids Res. 20:6413-6413 (1992)

Background Reference 04

Fan Z., Beresford P.J.Mol. Cell. Biol. 22:2810-2820 (2002)

Other Product Names

High mobility group protein B2, High mobility group protein 2, HMG-2, HMGB2, HMG2

Tested Applications

Protein ID

123374

Physical Properties

Liquid

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