NME3 Antibody
Product Specifications
Background
NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34 (+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.
NCBI Gene ID
4832
Swiss Prot
Q13232
Accession Number
Q13232
Host
Rabbit
Reactivity
Human
Immunogen
This NME3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the Central region of human NME3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
19 kDa
Fragment
Rabbit Ig
Symbol
NME3
NCBI Official Name
Nucleoside diphosphate kinase 3
NCBI Organism
Homo sapiens
Background Reference 01
Negroni, A., et al., Cell Death Differ. 7 (9) :843-850 (2000) .
Background Reference 02
Martinez, R., et al., Cancer Res. 57 (6) :1180-1187 (1997) .
Background Reference 03
Venturelli, D., et al., Proc. Natl. Acad. Sci. U.S.A. 92 (16) :7435-7439 (1995) .
Other Product Names
Nucleoside diphosphate kinase 3, NDK 3, NDP kinase 3, DR-nm23, Nucleoside diphosphate kinase C, NDPKC, nm23-H3, NME3
Tested Applications
WB, IHC-P
Protein ID
21264477
Physical Properties
Liquid
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
