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NME3 Antibody

Product Specifications

Background

NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34 (+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.

NCBI Gene ID

4832

Swiss Prot

Q13232

Accession Number

Q13232

Host

Rabbit

Reactivity

Human

Immunogen

This NME3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the Central region of human NME3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-690

Calculated Molecular Weight

19 kDa

Fragment

Rabbit Ig

Symbol

NME3

NCBI Official Name

Nucleoside diphosphate kinase 3

NCBI Organism

Homo sapiens

Background Reference 01

Negroni, A., et al., Cell Death Differ. 7 (9) :843-850 (2000) .

Background Reference 02

Martinez, R., et al., Cancer Res. 57 (6) :1180-1187 (1997) .

Background Reference 03

Venturelli, D., et al., Proc. Natl. Acad. Sci. U.S.A. 92 (16) :7435-7439 (1995) .

Other Product Names

Nucleoside diphosphate kinase 3, NDK 3, NDP kinase 3, DR-nm23, Nucleoside diphosphate kinase C, NDPKC, nm23-H3, NME3

Tested Applications

WB, IHC-P

Protein ID

21264477

Physical Properties

Liquid

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