CAMKK2 Antibody

Product Specifications

Background

CAMKK2 belongs to the Serine/Threonine protein kinase family, and to the Ca (2+) /calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. CAMKK2 appears to be involved in hippocampal activation of CREB1.

NCBI Gene ID

10645

Swiss Prot

Q96RR4

Accession Number

Q96RR4

Host

Rabbit

Reactivity

Human

Immunogen

This CAMKK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 483-512 amino acids from the C-terminal region of human CAMKK2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

65 kDa

Fragment

Rabbit Ig

Symbol

CAMKK2

NCBI Official Name

Calcium/calmodulin-dependent protein kinase kinase 2

NCBI Organism

Homo sapiens

Background Reference 01

Hsu, L.S., et al., J. Biol. Chem. 276 (33) :31113-31123 (2001) .

Background Reference 02

Hsu, L.S., et al., J. Biomed. Sci. 5 (2) :141-149 (1998) .

Background Reference 03

Anderson, K.A., et al., J. Biol. Chem. 273 (48) :31880-31889 (1998) .

Background Reference 04

Ishikawa, Y., et al., FEBS Lett. 550 (1-3), 57-63 (2000) .

Other Product Names

Calcium/calmodulin-dependent protein kinase kinase 2, CaM-KK 2, CaM-kinase kinase 2, CaMKK 2, Calcium/calmodulin-dependent protein kinase kinase beta, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta, CAMKK2, CAMKKB, KIAA0787