STK38 Antibody

Product Specifications

Background

Stk38, also known as NUCLEAR DBF2-RELATED PROTEIN, contains 1 protein kinase domain that interacts with mob1 and mob2.The homodimeric s100b binds to two molecules of stk38. It is ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Stk38 activated by binding of s100b which releases autoinhibitory n-lobe interactions, enabling atp to bind and the autophosphorylation of ser-281. thr-444 then undergoes calcium- dependent phosphorylation by an upstream kinase. Interactions between phosphorylated thr-444 and the n-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of mob1/mobkl1a and mob2/hcca2 to the n-terminal of stk38.

NCBI Gene ID

11329

Swiss Prot

Q15208

Accession Number

Q15208

Host

Rabbit

Reactivity

Human

Immunogen

This STK38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-439 amino acids from the C-terminal region of human STK38.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

54 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

STK38

NCBI Official Name

Serine/threonine-protein kinase 38

NCBI Organism

Homo sapiens

Background Reference 01

Devroe, E., et al., J. Biol. Chem. 279 (23) :24444-24451 (2004) .

Background Reference 02

Tamaskovic, R., et al., J. Biol. Chem. 278 (9) :6710-6718 (2003) .

Background Reference 03

Tripodis, N., et al., Genome Res. 8 (6) :631-643 (1998) .

Background Reference 04

Millward, T., et al., Proc. Natl. Acad. Sci. U.S.A. 92 (11) :5022-5026 (1995) .

Other Product Names

Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1, STK38 {ECO:0000312|EMBL:AAH120851}

Tested Applications

Protein ID

56749457

Physical Properties

Liquid

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