Enniatin B1

Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42) . Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3].

Product Specifications

CAS Number

[19914-20-6]

UNSPSC

12352005

Hazard Statement

H301+H311+H331

Target

Acyltransferase; ERK; NF-κB

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/enniatin-b1.html

Purity

99.34

Solubility

DMSO : ≥ 10 mg/mL

Smiles

CC[C@@H]([C@]1([H])N(C([C@H](OC([C@](N(C([C@@H](C(C)C)OC([C@H](C(C)C)N(C)C([C@](C(C)C)([H])OC1=O)=O)=O)=O)C)([H])C(C)C)=O)C(C)C)=O)C)C

Molecular Formula

C34H59N3O9

Molecular Weight

653.85

Precautions

H301+H311+H331

References & Citations

[1]Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo) . 1992 Oct;45 (10) :1626-32.|[2]Krug I, et al. Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. PLoS One. 2018 May 16;13 (5) :e0197406.|[3]Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53 (4) :431-40.