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AMPK gamma Antibody

Product Specifications

Background

PRKAG1 is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.

NCBI Gene ID

5571

Swiss Prot

P54619

Accession Number

P54619

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This AMPK gamma (PRKAG1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-295 amino acids from the Central region of human AMPK gamma (PRKAG1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-619

Calculated Molecular Weight

38 kDa

Fragment

Rabbit Ig

Symbol

PRKAG1

NCBI Official Name

5'-AMP-activated protein kinase subunit gamma-1

NCBI Organism

Homo sapiens

Background Reference 01

Minokoshi, Y., et al., Nature 428 (6982) :569-574 (2004) .

Background Reference 02

Hamilton, S.R., et al., FEBS Lett. 500 (3) :163-168 (2001) .

Background Reference 03

Zidovetzki, R., et al., AIDS Res. Hum. Retroviruses 14 (10) :825-833 (1998) .

Background Reference 04

Reinton, N., et al., Genomics 49 (2) :290-297 (1998) .

Other Product Names

5'-AMP-activated protein kinase subunit gamma-1, AMPK gamma1, AMPK subunit gamma-1, AMPKg, PRKAG1

Tested Applications

WB, IHC-P

Protein ID

1703037

Physical Properties

Liquid

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