Pyruvate Kinase Antibody
Product Specifications
Background
There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. PKM2 is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis.
NCBI Gene ID
5315
Swiss Prot
P14618
Accession Number
P14618
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
This Pyruvate Kinase (PKM2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-505 amino acids from the C-terminal region of human Pyruvate Kinase (PKM2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
58 kDa
Fragment
Rabbit Ig
Symbol
PKM
NCBI Official Name
Pyruvate kinase PKM
NCBI Organism
Homo sapiens
Background Reference 01
References for protein:
Background Reference 02
Williams, J.M., et al., Mol. Microbiol. 27 (1) :171-186 (1998) .
Background Reference 03
Gress, T.M., et al., Oncogene 13 (8) :1819-1830 (1996) .
Background Reference 04
Kato, H., et al., Proc. Natl. Acad. Sci. U.S.A. 86 (20) :7861-7865 (1989) .
Other Product Names
Pyruvate kinase PKM, Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58, PKM, OIP3, PK2, PK3, PKM2
Tested Applications
WB, IHC-P, IF
Protein ID
20178296
Physical Properties
Liquid
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