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PKLR Antibody

Product Specifications

Background

PKLR is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA) .

NCBI Gene ID

5313

Swiss Prot

P30613

Accession Number

P30613

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PKLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-551 amino acids from the C-terminal region of human PKLR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

62 kDa

Fragment

Rabbit Ig

Symbol

PKLR

NCBI Official Name

Pyruvate kinase PKLR

NCBI Organism

Homo sapiens

Background Reference 01

Wang, H., et al., Diabetes 51 (9) :2861-2865 (2002) .

Background Reference 02

Valentini, G., et al., J. Biol. Chem. 277 (26) :23807-23814 (2002) .

Background Reference 03

Mateu, E., et al., Hum. Genet. 110 (6) :532-544 (2002) .

Background Reference 04

Indo, Y., et al., Hum. Mutat. 18 (4) :308-318 (2001) .

Other Product Names

Pyruvate kinase PKLR, Pyruvate kinase 1, Pyruvate kinase isozymes L/R, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase, PKLR, PK1, PKL

Tested Applications

WB, IHC-P

Physical Properties

Liquid

Frequently Asked Questions

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