AKT2 Antibody

Product Specifications

Background

AKT2 is a putative oncogenic protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. Furthermore, AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins.

NCBI Gene ID

208

Swiss Prot

P31751

Accession Number

P31751

Host

Rabbit

Reactivity

Human

Immunogen

This AKT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-123 amino acids from the Central region of human AKT2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Immunology, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

56 kDa

Fragment

Rabbit Ig

Symbol

AKT2

NCBI Official Name

RAC-beta serine/threonine-protein kinase

NCBI Organism

Homo sapiens

Background Reference 01

Vojtek, A.B., et al., Mol. Cell. Biol. 23 (13) :4417-4427 (2003) .

Background Reference 02

Yuan, Z.Q., et al., J. Biol. Chem. 278 (26) :23432-23440 (2003) .

Background Reference 03

Jones, D.T., et al., Blood 101 (8) :3174-3180 (2003) .

Background Reference 04

Brozinick, J.T. Jr., et al., Diabetes 52 (4) :935-941 (2003) .

Other Product Names

RAC-beta serine/threonine-protein kinase, Protein kinase Akt-2, Protein kinase B beta, PKB beta, RAC-PK-beta, AKT2

Tested Applications

WB, IHC-P, IF, Flow

Protein ID

1170703

Physical Properties

Liquid

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