PKC zeta Antibody
Product Specifications
Background
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a constitutive kinase activity which is independent of calcium, and PKC activators, phosphatidylserine and diacylglycerol. Furthermore, it is insensitive to PKC inhibitors and cannot be activated by phorbol ester. The structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC.
NCBI Gene ID
5590
Swiss Prot
Q05513
Accession Number
Q05513
Host
Rabbit
Reactivity
Human
Immunogen
This PKC zeta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-197 amino acids from the N-terminal region of human PKC zeta.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Symbol
PRKCZ
NCBI Official Name
Protein kinase C zeta type
NCBI Organism
Homo sapiens
Background Reference 01
Li, Y.F., et al., World J. Gastroenterol. 9 (9) :2078-2082 (2003) .
Background Reference 02
Minami, T., et al., J. Biol. Chem. 278 (9) :6976-6984 (2003) .
Background Reference 03
Beeson, M., et al., Diabetes 52 (8) :1926-1934 (2003) .
Background Reference 04
Laudanna, C., et al., Lab. Invest. 83 (8) :1155-1163 (2003) .
Other Product Names
Protein kinase C zeta type, nPKC-zeta, PRKCZ, PKC2
Tested Applications
WB, IHC-P
Protein ID
68067736
Physical Properties
Liquid
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