AD_K2 Antibody
Product Specifications
Background
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
NCBI Gene ID
157
Swiss Prot
P35626
Accession Number
P35626
Host
Rabbit
Reactivity
Human, Mouse, Monkey
Immunogen
This AD_K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 633-660 amino acids from the C-terminal region of human AD_K2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=62-583
Calculated Molecular Weight
80 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ADRBK2
NCBI Official Name
Beta-adrenergic receptor kinase 2
NCBI Organism
Homo sapiens
Background Reference 01
Calabrese, G., et al., Genomics 23 (1) :286-288 (1994) . Parruti, G., et al., Biochem. Biophys. Res. Commun. 190 (2) :475-481 (1993) . Benovic, J.L., et al., J. Biol. Chem. 266 (23) :14939-14946 (1991) .
Other Product Names
Beta-adrenergic receptor kinase 2, Beta-ARK-2, G-protein-coupled receptor kinase 3, ADRBK2, BARK2, GRK3
Tested Applications
WB
Protein ID
116241253
Physical Properties
Liquid
Curated Selection
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