PAX6-T373 Antibody

Product Specifications

Background

PAX6 encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly.

NCBI Gene ID

5080

Swiss Prot

P26367

Accession Number

P26367

Host

Rabbit

Reactivity

Human, Rat

Immunogen

This PAX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-380 amino acids from human PAX6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

47 kDa

Fragment

Rabbit Ig

Symbol

PAX6

NCBI Official Name

Paired box protein Pax-6

NCBI Organism

Homo sapiens

Background Reference 01

Zhang, Y., et al. J. Biol. Chem. 285 (4) :2527-2536 (2010)

Background Reference 02

McGeachie, M., et al. Circulation 120 (24) :2448-2454 (2009)

Background Reference 03

Schmidt-Sidor, B., et al. Folia Neuropathol 47 (4) :372-382 (2009)

Background Reference 04

Ng, T.K., et al. Mol. Vis. 15, 2239-2248 (2009)

Other Product Names

Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2

Tested Applications

WB, IHC-P, IF

Protein ID

6174889

Physical Properties

Liquid

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