What is the catalog number for MTM1 Antibody?

The catalog number for MTM1 Antibody is 62-480.

What sizes are available for MTM1 Antibody?

MTM1 Antibody is available in the following size(s): 400 µL.

Is MTM1 Antibody in stock?

MTM1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

MTM1 Antibody

Product Specifications

Background

MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI (3) P) . Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI (3) P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI (3) P.

NCBI Gene ID

4534

Swiss Prot

Q13496

Accession Number

Q13496

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-594 amino acids from the C-terminal region of human MTM1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

70 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MTM1

NCBI Official Name

Myotubularin

NCBI Organism

Homo sapiens

Background Reference 01

Nandurkar, H.H., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (15) :8660-8665 (2003) .

Background Reference 02

Biancalana, V., et al., Hum. Genet. 112 (2) :135-142 (2003) .

Background Reference 03

Wishart, M.J., et al., Trends Cell Biol. 12 (12) :579-585 (2002) .

Background Reference 04

Herman, G.E., et al., Hum. Mutat. 19 (2) :114-121 (2002) .

Other Product Names

Myotubularin, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, MTM1, CG2

Tested Applications

Protein ID

2851537

Physical Properties

Liquid

Frequently Asked Questions

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