TPA Antibody
Product Specifications
Background
TPA is a tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.
NCBI Gene ID
5327
Swiss Prot
P00750
Accession Number
P00750
Host
Rabbit
Reactivity
Human
Immunogen
This TPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371-399 amino acids from the Central region of human TPA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Obesity
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=62-457
Calculated Molecular Weight
63 kDa
Fragment
Rabbit Ig
Symbol
PLAT
NCBI Official Name
Tissue-type plasminogen activator
NCBI Organism
Homo sapiens
Background Reference 01
De Vos, A.M., et.al., Biochemistry 31 (1), 270-279 (1992)
Background Reference 02
Bentov, Y., et.al., PLoS ONE (6), E5918 (2009)
Other Product Names
Tissue-type plasminogen activator, t-PA, t-plasminogen activator, tPA, Alteplase, Reteplase, Tissue-type plasminogen activator chain A, Tissue-type plasminogen activator chain B, PLAT
Tested Applications
WB, IHC-P, Flow
Protein ID
137119
Physical Properties
Liquid
Curated Selection
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