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MAPRE1 Antibody

Product Specifications

Background

The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family.

NCBI Gene ID

22919

Swiss Prot

Q15691

Accession Number

Q15691

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This MAPRE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-71 amino acids from the N-terminal region of human MAPRE1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=62-452

Calculated Molecular Weight

30 kDa

Fragment

Rabbit Ig

Symbol

MAPRE1

NCBI Official Name

Microtubule-associated protein RP/EB family member 1

NCBI Organism

Homo sapiens

Background Reference 01

Jaulin, F., et al. J. Cell Biol. 190 (3) :443-460 (2010)

Background Reference 02

Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

Background Reference 03

De Groot, C.O., et al. J. Biol. Chem. 285 (8) :5802-5814 (2010)

Background Reference 04

Jiang, K., et al. EMBO Rep. 10 (8) :857-865 (2009)

Other Product Names

Microtubule-associated protein RP/EB family member 1, APC-binding protein EB1, End-binding protein 1, EB1, MAPRE1

Tested Applications

WB, IHC-P, Flow

Protein ID

20138589

Physical Properties

Liquid

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